Three calculators clinicians actually reach for: dilution and units per 0.1 mL, unit conversion between toxin brands, and reference filler volume by facial zone. The maths runs in your browser — nothing is uploaded, nothing is stored.
Enter the vial size and the volume of saline you add. The calculator returns concentration per 0.1 mL, per unit, and the volume needed for any given dose.
Dysport is supplied as 300 U or 500 U; Botox and Xeomin commonly 50, 100 or 200 U.
| Diluent added to a 100 U vial | Dose per 0.1 mL | Dose per 0.01 mL |
|---|---|---|
| 1.0 mL | 10.0 U | 1.00 U |
| 2.0 mL | 5.0 U | 0.50 U |
| 2.5 mL | 4.0 U | 0.40 U |
| 4.0 mL | 2.5 U | 0.25 U |
| 8.0 mL | 1.25 U | 0.125 U |
Figures match the reconstitution tables published in manufacturers' instructions for use, calculated for a 0.1 mL injection volume. Injecting 0.05 mL halves the delivered dose; 0.15 mL increases it by half.
Units are not interchangeable between products — each manufacturer defines its own unit. The ratios below are the conversion figures most commonly cited in the literature and should be treated as approximate.
Auto-filled from the table below. Override it if your own protocol differs.
| Product | Active | Common ratio vs onabotulinumtoxinA | Vial sizes |
|---|---|---|---|
| Botox / Vistabel | onabotulinumtoxinA | 1 : 1 (reference) | 50, 100, 200 U |
| Xeomin / Bocouture | incobotulinumtoxinA | 1 : 1 | 50, 100 U |
| Jeuveau / Nuceiva | prabotulinumtoxinA | 1 : 1 | 100 U |
| Dysport / Azzalure | abobotulinumtoxinA | 1 : 2.5 (range 1:2–1:3 reported) | 300, 500 U |
| Daxxify | daxibotulinumtoxinA | 1 : 1 approximate | 50, 100 U |
| Botulax | Hugel, Korea | 1 : 1 | 50, 100, 150, 200, 300 U |
| Nabota | Daewoong, Korea | 1 : 1 | 100, 200 U |
| Meditoxin / Neuronox | Medytox, Korea | 1 : 1 | 50, 100, 150, 200 U |
| Liztox | Huons, Korea | 1 : 1 | 100, 200 U |
Reference volume ranges per zone, with a running total in mL and syringes. Ranges are typical published starting volumes, not a treatment plan.
| Zone | Typical range | Planned, mL |
|---|
Tick the areas to get a total dose and the volume for the dilution set on the first tab. Units are for products with a 1:1 relationship to onabotulinumtoxinA; Dysport must be converted separately.
| Area and muscle | U per point | Points | Total, U |
|---|---|---|---|
|
Frontalis · intradermal |
1–2 | 5–7 | 5–14 |
|
Corrugator, procerus · intramuscular |
2–4 | 5–7 | 10–28 |
|
Orbicularis oculi · intradermal |
2–4 | 6 | 12–24 |
|
Orbicularis oculi, lower · intradermal |
0,5–1 | 2–4 | 1–4 |
|
Orbicularis oculi · intradermal |
1,25–2,5 | 10–12 | 12.5–30 |
|
LLSAN, levator labii · intramuscular |
2–3 | 1–2 | 2–6 |
|
Orbicularis oris, vermilion · intradermal |
0,2–0,5 | 4–9 | 0.8–4.5 |
|
Depressor anguli oris · intramuscular |
2–4 | 2 | 4–8 |
|
Depressor labii inferioris · intramuscular |
4–6 | 2 | 8–12 |
|
Mentalis · intramuscular |
2–4 | 2–3 | 4–12 |
|
Masseter · intramuscular |
20–30 | 2 | 40–60 |
|
Platysma · intradermal |
1–2 | 6–12 | 6–24 |
|
Intradermal, per area · intradermal |
— | сетка 1–2 см | 50–100 |
|
Intradermal, per area · intradermal |
— | сетка 1–2 см | 100–200 |
|
Intradermal, per area · intradermal |
— | сетка 1–2 см | 100–200 |
|
Gastrocnemius · intramuscular |
50–100 | по разметке | 100–200 |
Mapping the sweating area before injection.
| Step | Method |
|---|---|
| Solution | 1.5 g iodine, 100 mL 95% ethanol, 10 mL castor oil |
| Application | Thin layer on the skin, allow 5 minutes to dry |
| Starch | Dust with dry starch powder in a thin layer |
| Provocation | 500 W lamp at 50 cm for a few minutes |
| Result | Sweating sites turn dark brown — the injection grid is mapped on them |
| Review | Assess at 2 weeks; repeat session if the effect is insufficient |
Reported side effect: reduced grip strength when treating the palms.
Two different things that often get mixed up: what the manufacturer's leaflet states, and what is common practice in clinic. Both are shown separately below.
| Product | Per manufacturer IFU | Common clinic practice |
|---|---|---|
| Reconstituted botulinum toxin | Use within 24 hours, store at 2–8 °C | Up to 1 month refrigerated at 2–8 °C |
| Opened filler syringe | Single use, discard remainder | Up to 3 months refrigerated for top-ups |
| Unopened toxin vial | 2–8 °C for the full shelf life | Same |
| Unopened filler | 2–25 °C, do not freeze | Same |
Beyond three months there is no practical point in keeping an opened filler. The "common practice" column reports what is widely done, not a manufacturer recommendation; departing from the IFU is the clinician's responsibility.
Divide the vial size by the volume of saline added, then divide by ten. A 100 U vial reconstituted with 2 mL gives 50 U per mL, therefore 5 U per 0.1 mL. The calculator above does this and also gives the reverse figure — the volume required for a chosen dose.
No. The total number of units in the vial does not change. What changes is concentration: the same dose sits in a larger volume, so it is delivered over a wider area. That is a spread and precision decision, not a potency one.
Because a "unit" is defined by each manufacturer's own assay, not by a shared standard. onabotulinumtoxinA, incobotulinumtoxinA and prabotulinumtoxinA are usually treated as roughly one-to-one, whereas abobotulinumtoxinA is most often cited around 1:2.5. Published ranges vary, which is why the ratio field is editable.
They are volume markings. On a U-100 syringe, 100 marks equal 1 mL, so one mark is 0.01 mL. If your dilution gives 5 U per 0.1 mL, then each syringe mark carries 0.5 U.
No. Every calculation runs in your browser. There is no account, no upload and no analytics on the inputs.